In March 2002, in Los Angeles, she played the role of Pamina, and later in 2005 in Washington as well. In 2006, Andrea Rost was invited to Madrid to the Teatro Real to sing Blanche in Poulenc’s opera, Les dialogues des Carmélites. She has several times been a guest singer in the US for the Chicago Lyric Opera where she interpreted Zerlina, Gilda, Violetta, Giulietta and Michaela. In 1996, she sang for the first time on the stage of the New York Metropolitan Opera in the role of Adina in Donizetti’s L’Elisir d’Amore, later she also appeared there as Gilda, Lucia, and Violetta. Most recently, in 2006, she sang Susanna at the Metropolitan for Mozart’s Le Nozze di Figaro. She interpreted Antonia in Les Contes d’Hoffmann at the Washington National Opera, then later sang the same role in Los Angeles.

In 2009-2010, in the Hungarian State Opera, she sang the role of Euridice in L'anima del filosofo, ossia Orfeo ed Euridice, conducted by Ádám Fischer. Making her debut in Puccini’s Madama Butterfly in 2013, in Budapest, was the beginning of a new chapter in the life of Andrea Rost.